Pogostemon benghalensis leaves have traditionally been utilized for relieving\nbody aches, headaches and fever. Based on its uses, the present study was designed to investigate the\nantinociceptive, antipyretic and anti-edematogenic activities from P. benghalensis leavesâ?? methanol\nextract (PBME) inWister rats. Methods: The thermal (hot plate) and chemical (acetic acid-induced\nwrithing and formalin test) models for antinociceptive effects, and the Brewerâ??s yeast induced\nhyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic\nactivity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral\nroute was performed to determine the lethal dose. Results: PBME significantly and dose-dependently\nreduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic\neffects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency\nof licking indicated that PBME has significant dose-dependent antinociceptive activity. P. benghalensis\nmethanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of\nsafety. Conclusions: The study illustrated the antipyretic, antinociceptive and anti-inflammatory\npotential of P. benghalensis leaf extract with a safety margin, and validated its traditional use to\nalleviate fever, pain, and inflammation.
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